ABSTRACT
Introduction@#Researchers have found that people living in polluted areas have a lower ability to resist skin bacteria and increase the number of skin microflora. Decreased immune function increases the risk of sore throat, influenza, respiratory infections, pneumonia and gastrointestinal diseases. One of the main indicators of the human immune system is the normal microflora.@*Goal@#To study the relationship between normal human microflora and specific immunity.@*Material and Methods@#This study was conducted within the framework of the project “Effects of non-specific immune factors on injectable infectious disease immune system”. The survey sampled 10 households from Dornod aimag, 8th khoroo of Chingeltei district, Ulaanbaatar city, and 3rd khoroo of Baganuur district. A total of 176 people aged 6 months to 50 years were involved. A total of 528 swab samples and 31 blood samples were collected from the throat, tonsils, skin and mucous membranes to study the relationship between normal human microflora and specific immunity.</br> The research methodology was discussed at the meeting of the Academic Council of the Ministry of Social Welfare and the Medical Ethics Review Committee under the Ministry of Health (January 5, 2018, Resolution 646) and the research was approved.@*Results@#The total number of normal microorganisms in the skin and mucous membranes of the study participants changed, and the number of hemolytic strains and fungi increased. 58%-67% of the participants had normal and long-term immunity against diphtheria and tetanus, while 5% -14% were not. This result was as high as in urban and rural areas.@*Conclusion@#This result was as high as in urban and rural areas. As the age group increases, the level of the body’s specific immunity decreases, the structure of the normal microflora changes, and the number of fungi and hemolytic bacteria increases. Furthermore, it is necessary to study specific and nonspecific immunity in detail in relation to environmental pollution indicators.